There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

B-cell receptor-associated protein 31 (BAP31 or BCAP31) is a ubiquitously expressed
transmembrane protein found mainly in the endoplasmic reticulum (ER), including in …

Background Incontinentia pigmenti (IP) is a rare multisystemic X‐linked dominant genetic
disorder characterized by highly diagnostic skin lesions. The disease can be misdiagnosed …

Worldwide, more than 20 million people suffer from schizophrenia, but effective and
definitive new therapeutic drugs/treatments have not been established. Vasoactive intestinal …

Pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) is a
multifunctional neuropeptide involved in brain development and synaptic plasticity. With …

Despite recent leaps in modern medicine, progress in the treatment of neurological diseases
remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of …

Abstract Changes at the molecular level capacitate the plasticity displayed by the brain in
response to stress stimuli. Weaning stress can trigger molecular changes that influence the …

Simple Summary Before genomes were sequenced, zoologists had discovered destabilizing
selection as a general pattern of animal domestication that in foxes and minks had yielded …

Background: The gut-brain axis (GBA) is a bidirectional signaling channel that facilitates
communication between the gastrointestinal tract and the brain. Recent research on the gut …

Clinical studies have shown that microduplications at 7q36. 3, containing VIPR2, confer
significant risk for schizophrenia and autism spectrum disorder (ASD). VIPR2 gene encodes …