Primary cilia are small, antenna-like organelles that detect and transduce chemical and
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …

The assembly and maintenance of most cilia and eukaryotic flagella depends on
intraflagellar transport (IFT), the bidirectional movement of multi-megadalton IFT trains along …

Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory
organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular …

Intraflagellar transport (IFT) complexes, IFT-A and IFT-B, form bidirectional trains that move
along the axonemal microtubules and are essential for assembling and maintaining cilia …

Organ fibrosis is a shared endpoint of many diseases, yet underlying mechanisms are not
well understood. Several pathways governed by the primary cilium, a sensory antenna …

Cilia sense and transduce extracellular signals via specific receptors. The intraflagellar
transport (IFT) machinery mediates not only bidirectional protein trafficking within cilia but …

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …

The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for
function. The tubby family protein TULP3 transports integral membrane proteins into cilia …

The primary cilium is an organelle essential for cell signaling pathways. One of the most
common human genetic diseases is autosomal dominant polycystic kidney disease …