ABSTRACT BACKGROUND AND PURPOSE Spinal cord atrophy (SCA) is an important
emerging outcome measure in multiple sclerosis (MS); however, there is limited consensus …

The spinal cord is a clinically important site that is affected by pathological changes in most
patients with multiple sclerosis; however, imaging of the spinal cord with conventional MRI …

Objective A major challenge in multiple sclerosis (MS) research is the understanding of
silent progression and Progressive MS. Using a novel method to accurately capture upper …

The field of spinal cord MRI is lacking a common template, as existing for the brain, which
would allow extraction of multi-parametric data (diffusion-weighted, magnetization transfer …

Importance In multiple sclerosis (MS), upper cervical cord gray matter (GM) atrophy
correlates more strongly with disability than does brain or cord white matter (WM) atrophy …

Background: Spinal cord (SC) affection is a hallmark symptom of neuromyelitis optica
spectrum disorders (NMOSD). Patients with aquaporin-4 (AQP4-IgG+) or myelin …

Segmenting the spinal cord contour is a necessary step for quantifying spinal cord atrophy in
various diseases. Delineating gray matter (GM) and white matter (WM) is also useful for …

Objective To assess whether cervical spinal cord atrophy heralds the onset of progressive
MS. Methods We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 …

Objective To characterize the distribution and regional evolution of cervical cord atrophy in
patients with multiple sclerosis (MS) in a multicenter dataset. Methods MRI and clinical …

ABSTRACT BACKGROUND AND PURPOSE The quantification of spinal cord (SC) atrophy
by MRI has assumed an important role in assessment of neuroinflammatory …