The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Covering: 2008 to 2023 This review will describe oxidative phenol coupling as applied in the
total synthesis of natural products. This review covers catalytic and electrochemical methods …

Conspectus The total synthesis of structurally complex natural products has challenged and
inspired generations of chemists and remains an exciting area of active research. Despite …

Filamentous fungi produce a very wide range of complex and often bioactive metabolites,
demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent …

Controlling the selectivity of a reaction is critical for target-oriented synthesis. Accessing
complementary selectivity profiles enables divergent synthetic strategies, but is challenging …

Prenylated indole alkaloids featuring spirooxindole rings possess a 3 R or 3 S carbon
stereocenter, which determines the bioactivities of these compounds. Despite the …

More food production required to feed humans will require intensive use of herbicides to
protect against weeds. The widespread application and persistence of herbicides pose …

Understanding the general mechanism of the metal-free and cofactor-free oxidases and
oxygenases catalyzed activation of triplet O2 is one of the most challenging questions in the …

Flavoenzymes can mediate a large variety of oxidation reactions through the activation of
oxygen. However, the O2 activation chemistry of flavin enzymes is not yet fully exploited …