Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …

The Hippo pathway is a universal governor of organ size, tissue homeostasis, and
regeneration. A growing body of work has advanced our understanding of Hippo pathway …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Antiangiogenic and cytotoxic effects are considered the principal mechanisms of action of
sorafenib, a multitarget kinase inhibitor approved for the treatment of hepatocellular …

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo,
down-regulated at birth and then reappears in tumors. Its role in tumor initiation and …

Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of
hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated …

With the rapid expansion of the obesity epidemic, nonalcoholic fatty liver disease is now the
most common chronic liver disease, with almost 25% global prevalence. Nonalcoholic fatty …

The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells,
but its role in cell fate determination and differentiation during liver development remains …