Sodium bicarbonate (NaHCO3) has been recognized as a possible therapy to target chronic
kidney disease (CKD) progression. Several small clinical trials have demonstrated that …

The 5/6 nephrectomy rat remnant kidney model is commonly used to study chronic kidney
disease (CKD). This model requires the removal of one whole kidney and two-thirds of the …

Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and
tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the …

Background Abnormal renal hemodynamic responses to salt‐loading are thought to
contribute to salt‐sensitive (SS) hypertension. However, this is based largely on studies in …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …

Ca2+ is an important second messenger that translates extracellular stimuli into intracellular
responses. Although there has been significant progress in understanding Ca2+ dynamics …

Different machine learning approaches for analyzing renal hemodynamics using time series
of arterial blood pressure and renal blood flow rate measurements in conscious rats are …

The first planned clinical unilateral nephrectomy was performed by Dr. Gustav Simon in
1869. Gustav Simon, a Professor of Surgery in Heidelberg, Germany, had been treating a …

A convolutional deep neural network is employed to assess renal autoregulation using time
series of arterial blood pressure and blood flow rate measurements in conscious rats. The …

Sodium bicarbonate (NaHCO 3) is a therapeutic used in chronic kidney disease (CKD).
NaHCO 3 is typically used to treat metabolic acidosis, but clinical studies have indicated that …