Ultra‐high dose rate dosimetry: challenges and opportunities for FLASH radiation therapy

F Romano, C Bailat, PG Jorge, MLF Lerch… - Medical …, 2022 - Wiley Online Library
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

A Lourenço, A Subiel, N Lee, S Flynn, J Cotterill… - Scientific Reports, 2023 - nature.com
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short
pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly …

Flash irradiation with proton beams: beam characteristics and their implications for beam diagnostics

KP Nesteruk, S Psoroulas - applied sciences, 2021 - mdpi.com
FLASH irradiations use dose-rates orders of magnitude higher than commonly used in
patient treatments. Such irradiations have shown interesting normal tissue sparing in cell …

Characterization of LiF: Mg, Ti thermoluminescence detectors in low-LET proton beams at ultra-high dose rates

S Motta, JB Christensen, M Togno… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. This work aims at characterizing LiF: Mg, Ti thermoluminescence detectors (TLDs)
for dosimetry of a 250 MeV proton beam delivered at ultra-high dose rates (UHDR). Possible …

A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply

W Zou, H Kim, ES Diffenderfer, DJ Carlson… - Frontiers in …, 2022 - frontiersin.org
Introduction Radiation-induced oxygen depletion in tissue is assumed as a contributor to the
FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in …

[HTML][HTML] Ultra-high dose rate dosimetry for pre-clinical experiments with mm-small proton fields

M Togno, KP Nesteruk, R Schäfer, S Psoroulas, D Meer… - Physica Medica, 2022 - Elsevier
Purpose To characterize an experimental setup for ultra-high dose rate (UHDR) proton
irradiations, and to address the challenges of dosimetry in millimetre-small pencil proton …

Consistency of Faraday cup and ionization chamber dosimetry of proton fields and the role of nuclear interactions

J Wulff, A Paul, CM Bäcker, KS Baumann… - Medical …, 2024 - Wiley Online Library
Abstract Background A Faraday cup (FC) facilitates a quite clean measurement of the proton
fluence emerging from clinical spot‐scanning nozzles with narrow pencil‐beams. The …

Detailed Monte‐Carlo characterization of a Faraday cup for proton therapy

J Ehwald, M Togno, AJ Lomax, DC Weber… - Medical …, 2023 - Wiley Online Library
Background Experiments with ultra‐high dose rates in proton therapy are of increasing
interest for potential treatment benefits. The Faraday Cup (FC) is an important detector for …

Beam monitor chamber calibration of a synchro-cyclotron high dose rate per pulse pulsed scanned proton beam

M Vidal, A Gérard, V Floquet… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. Ionization chambers, mostly used for beam calibration and for reference
dosimetry, can show high recombination effects in pulsed high dose rate proton beams. The …

In situ correction of recombination effects in ultra-high dose rate irradiations with protons

R Schaefer, S Psoroulas… - Physics in Medicine & …, 2023 - iopscience.iop.org
Background. At the Center for Proton Therapy at the Paul Scherrer Institute (PSI) the delivery
of proton radiation is controlled via gas-based ionization chambers: the beam is turned off …