[HTML][HTML] Platelet secretion: From haemostasis to wound healing and beyond
EM Golebiewska, AW Poole - Blood reviews, 2015 - Elsevier
Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis
(NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we …
(NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we …
Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity
G Lopez-Herrera, G Tampella… - The American Journal of …, 2012 - cell.com
Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently
not well understood. Most affected individuals are simplex cases, but both autosomal …
not well understood. Most affected individuals are simplex cases, but both autosomal …
[HTML][HTML] The life cycle of platelet granules
A Sharda, R Flaumenhaft - F1000Research, 2018 - ncbi.nlm.nih.gov
Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …
cycle. Platelets contain three major granule types—dense granules, α-granules, and …
Platelets and cancer: a casual or causal relationship: revisited
Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …
The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases
Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …
Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation
KR Machlus, JN Thon… - British journal of …, 2014 - Wiley Online Library
Platelets are essential for haemostasis, and thrombocytopenia (platelet counts< 150× 109/l)
is a major clinical problem encountered across a number of conditions, including immune …
is a major clinical problem encountered across a number of conditions, including immune …
Lysosome-related organelles: unusual compartments become mainstream
MS Marks, HFG Heijnen, G Raposo - Current opinion in cell biology, 2013 - Elsevier
Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …
compartments with unique composition, morphology and structure that share some features …
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia
Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML).
Although additional genetic alterations play a central role in BC, the landscape and …
Although additional genetic alterations play a central role in BC, the landscape and …