The role of the cerebellum in classical conditioning of discrete behavioral responses

RF Thompson, JE Steinmetz - Neuroscience, 2009 - Elsevier
The cerebellum and its associated circuitry constitutes the entire essential neuronal system
for classical conditioning of eye-blink and other discrete responses (eg limb flexion) learned …

Mechanisms of cerebellar learning suggested by eyelid conditioning

JF Medina, WL Nores, T Ohyama, MD Mauk - Current opinion in …, 2000 - Elsevier
Classical eyelid conditioning has been used to great advantage in demonstrating that the
cerebellum helps to improve movements through experience, and in identifying the …

Coincidence detection in single dendritic spines mediated by calcium release

SSH Wang, W Denk, M Häusser - Nature neuroscience, 2000 - nature.com
Cerebellar long-term depression (LTD) is a calcium-dependent process in which coincident
activity of parallel fiber (PF) and climbing fiber (CF) synapses causes a long-lasting …

A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum.

MD Mauk, NH Donegan - Learning & memory, 1997 - learnmem.cshlp.org
We present a model based on the synaptic and cellular organization of the cerebellum to
derive a diverse range of phenomena observed in Pavlovian eyelid conditioning. These …

Neural learning rules for the vestibulo-ocular reflex

JL Raymond, SG Lisberger - Journal of Neuroscience, 1998 - Soc Neuroscience
Mechanisms for the induction of motor learning in the vestibulo-ocular reflex (VOR) were
evaluated by recording the patterns of neural activity elicited in the cerebellum by a range of …

On climbing fiber signals and their consequence (s)

JI Simpson, DR Wylie, CI De Zeeuw - Behavioral and Brain Sciences, 1996 - cambridge.org
The persistence of many contrasting notions of climbing fiber function after years of
investigation testifies that the issue of climbing fiber contributions to cerebellar transactions …

Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression

V Lev-Ram, T Jiang, J Wood, DS Lawrence, RY Tsien - Neuron, 1997 - cell.com
Parallel fiber synapses onto Purkinje neurons in acute cerebellar slices undergo long-term
depression (LTD) when presynaptic activity coincides with postsynaptic depolarization …

Intracellular correlates of acquisition and long-term memory of classical conditioning in Purkinje cell dendrites in slices of rabbit cerebellar lobule HVI

BG Schreurs, PA Gusev, D Tomsic… - Journal of …, 1998 - Soc Neuroscience
Intradendritic recordings in Purkinje cells from a defined area in parasaggital slices of
cerebellar lobule HVI, obtained after rabbits were given either paired (classical conditioning) …

Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses

NA Hartell - Neuron, 1996 - cell.com
The temporal and spatial changes in intracellular calcium levels during separate activation
of parallel fiber (PF) and climbing fiber (CF) inputs to cerebellar Purkinje cells were studied …

Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients

V Lev-Ram, LR Makings, PF Keitz, JPY Kao, RY Tsien - Neuron, 1995 - cell.com
The role of nitric oxide (NO) in the induction of longterm depression (LTD) in the cerebellum
was explored using a new, organic, membrane-impermeant form of caged NO. NO …