The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

Hypertension is a multifaceted disease that is involved in∼ 40% of cardiovascular
mortalities and is the result of both genetic and environmental factors. Because of its …

Since the identification of the alternative angiotensin converting enzyme (ACE) 2/Ang‐(1‐
7)/Mas receptor axis, renin‐angiotensin system (RAS) is a new complex target for a …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

The renin-angiotensin system (RAS) is well-recognized as one of the oldest and most
important regulators of arterial blood pressure, cardiovascular, and renal function. New …

The renin-angiotensin system (RAS) has been known for more than a century as a cascade
that regulates body fluid balance and blood pressure. Angiotensin II (Ang II) has many …

The concept of local formation of angiotensin II in the kidney has changed over the last 10–
15 years. Local synthesis of angiotensinogen in the proximal tubule has been proposed …

The renin–angiotensin system (RAS) is widely recognized as one of the most important
vasoactive hormonal systems in the physiological regulation of blood pressure and the …

Augmented intratubular angiotensin (ANG) II is a key determinant of enhanced distal Na+
reabsorption via activation of epithelial Na+ channels (ENaC) and other transporters, which …

The prorenin receptor (PRR), a recently discovered component of the renin-angiotensin
system, is expressed in the nephron in general and the collecting duct in particular …