Epidemiological evidence indicates that regular physical activity and/or frequent structured
exercise reduces the incidence of many chronic diseases in older age, including …

Immunosenescence is characterized by deterioration of the immune system caused by
aging which induces changes to innate and adaptive immunity. Immunosenescence affects …

Telomeres protect the integrity of information-carrying DNA by serving as caps on the
terminal portions of chromosomes. Telomere length decreases with aging, and this …

The integrity and composition of the tumour microenvironment (TME) is highly plastic,
undergoing constant remodelling in response to instructive signals derived from alterations …

Aging is associated with a decline in autophagy and a state of low-grade inflammation which
further affects apoptosis and autophagy. Importantly, these alterations could reverse with …

Aging is a risk factor for several pathologies, restricting one's health span, and promoting
chronic diseases (eg, cardiovascular and neurodegenerative diseases), as well as cancer …

Age-associated hyper-inflammation or “inflamm-aging” has been linked to the development
of chronic diseases and characterized as an unavoidable aspect of aging. However, the …

Study design Family members caring for chronically ill relatives are typically sedentary,
chronically stressed, and at high risk of disease. Observational reports suggest caregivers …

Undertaking a high volume of physical activity is associated with reduced risk of a broad
range of clinically diagnosed cancers. These findings, which imply that physical activity …

Regular physical activity is effective as prevention and treatment for different chronic
conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a …