Injectable hydrogels are being developed as potential translatable materials to influence the
cascade of events that occur after myocardial infarction. These hydrogels, consisting of both …

Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

A recent trend has emerged that involves myocardial injection of biomaterials, containing
cells or acellular, following myocardial infarction (MI) to influence the remodeling response …

Fibrosis is the formation or development of excess fibrous connective tissue (largely type I
collagen) in a tissue as a result of a reparative or reactive process. Fibrosis, or scarring, is a …

Myocardial remodeling, including ventricular dilation and wall thinning, is an important
pathological process caused by myocardial infarction (MI). To intervene in this pathological …

Purpose: To prospectively evaluate a gadolinium-based collagen-targeting contrast agent,
EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse …

Increased myocardial wall stress after myocardial infarction (MI) initiates the process of
adverse left ventricular (LV) remodeling that is manifest as progressive LV dilatation, loss of …

Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling
after myocardial infarction (MI). Although studies have shown that injectable hydrogels …

After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …

The ability to trace or identify specific molecules within a specific anatomic location provides
insight into metabolic pathways, tissue components, and tracing of solute transport …