Peptide-based therapeutic vaccines for allergic and autoimmune diseases

M Larche, DC Wraith - Nature medicine, 2005 - nature.com
Allergic and autoimmune diseases are forms of immune hypersensitivity that increasingly
cause chronic ill health. Most current therapies treat symptoms rather than addressing …

Myasthenia gravis: autoantibody specificities and their role in MG management

K Lazaridis, SJ Tzartos - Frontiers in neurology, 2020 - frontiersin.org
Myasthenia gravis (MG) is the most common autoimmune disorder affecting the
neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is …

[HTML][HTML] Current treatment, emerging translational therapies, and new therapeutic targets for autoimmune myasthenia gravis

JT Guptill, M Soni, MN Meriggioli - Neurotherapeutics, 2016 - Elsevier
Myasthenia gravis (MG) is an autoimmune disease associated with the production of
autoantibodies against 1) the skeletal muscle acetylcholine receptor; 2) muscle-specific …

[HTML][HTML] Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities

SM Anderton - Immunology, 2001 - ncbi.nlm.nih.gov
Our understanding of the basic mechanisms controlling the generation of productive
immunity continues to evolve at a great pace. Models of how the immune response may be …

Glatiramer acetate in the treatment of multiple sclerosis

M Sela, D Teitelbaum - Expert opinion on pharmacotherapy, 2001 - Taylor & Francis
This review article summarises the initial preclinical studies as well as the different stages of
clinical trials in multiple sclerosis (MS) with Copolymer 1 (Cop 1), recently denoted …

The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand

H Ben-David, A Sharabi, M Dayan… - Proceedings of the …, 2007 - National Acad Sciences
Myasthenia gravis (MG) and experimental autoimmune MG are T cell-dependent antibody-
mediated autoimmune diseases. A dual altered peptide ligand (APL), composed of the …

Autoantigen complementarity: a new theory implicating complementary proteins as initiators of autoimmune disease

WF Pendergraft, BM Pressler, JC Jennette… - Journal of molecular …, 2005 - Springer
Autoimmune diseases affect approximately 1 in 21 persons in the United States. Treatment
often requires long-term cytotoxic therapy. How and why these deleterious diseases occur is …

Therapeutic vaccines in autoimmunity

M Sela, E Mozes - Proceedings of the National Academy of …, 2004 - National Acad Sciences
Similarly to prophylactic vaccines whose purpose is to prevent infectious diseases,
therapeutic vaccines against autoimmune diseases are based on their similarity to the …

Myasthenia gravis: State of the art and new therapeutic strategies

EB Souto, B Lima, JR Campos… - Journal of …, 2019 - Elsevier
Myasthenia Gravis (MG)–an autoimmune neuromuscular disease–is known by the
production of autoantibodies against components of the neuromuscular junction mainly to …

The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by …

M Paas-Rozner, M Sela… - Proceedings of the …, 2001 - National Acad Sciences
Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T-cell regulated,
antibody-mediated diseases. Peptides p195–212 and p259–271 of the human acetylcholine …