Publisher Summary Most strains of the yeast, Saccharomyces cerevisiae, harbor about 100
copies of an autonomously replicating plasmid, the 2-μm plasmid. Although the plasmid …

This review focuses on two of the approximately 30 members of the diverse Int family of site-
specific recombinases. The λ recombination system represents those reactions involving …

Replication fork collision with a DNA nick can generate a one-ended break, fostering
genomic instability. The opposing fork's collision with the nick could form a second DNA end …

The three-dimensional structure of the dimeric transmembrane domain of glycophorin A
(GpA) was determined by solution nuclear magnetic resonance spectroscopy of a 40 …

Alignments of 105 site-specific recombinases belonging to the Int family of proteins identified
extended areas of similarity and three types of structural differences. In addition to the …

The integrases are a diverse family of tyrosine recombinases which rearrange DNA
duplexes by means of conservative site-specific recombination reactions. Members of this …

IN mammals, the testis determining gene (TDF), present on the Y chromosome, induces the
undifferentiated gonads to form testes1. The position of TDF on the human Y chromosome …

Summary Suppressor of Hairless (Su (H)) is required at two stages of adult sensory organ
development in Drosophila. Complete loss of Su (H) function results in a 'neurogenic” …

Lambda integrase is archetypic of site-specific recombinases that catalyze intermolecular
DNA rearrangements without energetic input. DNA cleavage, strand exchange, and …

Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA-(3′-
phosphotyrosyl)-enzyme intermediate. A C-terminal catalytic domain, Topo (81–314) …