The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

Spinocerebellar ataxias (SCAs) constitute a heterogeneous group of more than 30
autosomal-dominant genetic and neurodegenerative disorders. SCAs are generally …

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited,
neurodegenerative disease caused by an expansion of polyglutamine tracts in the cytosolic …

The contribution of neuronal dysfunction to neurodegeneration is studied in a mouse model
of spinocerebellar ataxia type 1 (SCA1) displaying impaired motor performance ahead of …

Neuronal atrophy in neurodegenerative diseases is commonly viewed as an early event in a
continuum that ultimately results in neuronal loss. In a mouse model of the polyglutamine …

Abstract Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by
the expansion of a polyglutamine repeat within the disease protein, ataxin 1. To elucidate …

Neurodegenerative diseases (NDDs) involve years of gradual preclinical progression. It is
widely anticipated that in order to be effective, treatments should target early stages of …

Abstract Spinocerebellar ataxia type 6 (SCA6) is a devastating midlife-onset autosomal
dominant motor control disease with no known treatment. Using a hyper-expanded …

The spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative
diseases that share convergent disease features. A common symptom of these diseases is …

In a transgenic mouse model of the neurodegenerative disorder Huntington's disease (HD),
age-dependent neurologic defects are accompanied by progressive alterations in glucose …