Doxorubicin or Adriamycin, is one of the most widely used chemotherapeutic drug for
treating a myriad of cancers. It induces cell death through multiple intracellular targets …

The development of heterocyclic derivatives has progressed considerably over the past few
decades, and many new agents of synthetic and natural origin have been produced. Among …

Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …

Background and Purpose Catalpol, a water‐soluble active ingredient isolated from
Rehmannia glutinosa, exhibits multiple pharmacological activities. However, the mechanism …

Doxorubicin (DOX) is a well-known anti-neoplastic agent that is widely employed to treat
several types of malignancies. The current study was designed to investigate the …

One of the most important side effects of Doxorubicin (DOX), a chemotherapeutic agent, is
nephrotoxicity. The purpose of this study is to determine whether different doses of natural …

Ethnopharmacological relevance: Oxidative stress is a key player in intestinal
ischemia/reperfusion (I/R) injury (IIRI) with a tendency to trigger systemic inflammatory …

Nicorandil ameliorated doxorubicin-induced nephrotoxicity; this study aimed to show and
explain the mechanism of this protection. A precise method was elucidated to study the …

Background: Activation of caspase 3 has been implicated in the pathogenesis of I/R injury in
various organs, but there is a paucity of data on its role in IIRI. Also, no reports were found …

The present study was designed to investigate the potential protective effects of diosmin
(DS) and/or sildenafil against bile duct ligation (BDL). In order to achieve this goal, BDL was …