Complex cocktails: the evolutionary novelty of venoms

NR Casewell, W Wüster, FJ Vonk, RA Harrison… - Trends in ecology & …, 2013 - cell.com
Venoms have evolved on numerous occasions throughout the animal kingdom. These
'biochemical weapon systems' typically function to facilitate, or protect the producing animal …

Snake venom metalloproteinases

FS Markland Jr, S Swenson - Toxicon, 2013 - Elsevier
Recent proteomic analyses of snake venoms show that metalloproteinases represent major
components in most of the Crotalid and Viperid venoms. In this chapter we discuss the …

Venomics: integrative venom proteomics and beyond

JJ Calvete - Biochemical Journal, 2017 - portlandpress.com
Venoms are integrated phenotypes that evolved independently in, and are used for
predatory and defensive purposes by, a wide phylogenetic range of organisms. The same …

Snakebite envenoming diagnosis and diagnostics

C Knudsen, JA Jürgensen, S Føns, AM Haack… - Frontiers in …, 2021 - frontiersin.org
Snakebite envenoming is predominantly an occupational disease of the rural tropics,
causing death or permanent disability to hundreds of thousands of victims annually. The …

[HTML][HTML] Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms

B Lomonte, JJ Calvete - Journal of Venomous Animals and Toxins …, 2017 - SciELO Brasil
This work offers a general overview on the evolving strategies for the proteomic analysis of
snake venoms, and discusses how these may be combined through diverse experimental …

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

DJ Williams, JM Gutiérrez, JJ Calvete, W Wüster… - Journal of …, 2011 - Elsevier
The development of snake antivenoms more than a century ago should have heralded
effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural …

Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead

JM Gutiérrez, G Solano, D Pla, M Herrera, Á Segura… - Toxins, 2017 - mdpi.com
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming.
The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to …

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability …

JJ Calvete, L Sanz, A Pérez, A Borges, AM Vargas… - Journal of …, 2011 - Elsevier
We describe two geographically differentiated venom phenotypes across the wide
distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley through …

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by …

D Petras, L Sanz, A Segura, M Herrera… - Journal of proteome …, 2011 - ACS Publications
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica,
and N. pallida revealed similar compositional trends. The high content of cytotoxins and …

Snake venomics: from the inventory of toxins to biology

JJ Calvete - Toxicon, 2013 - Elsevier
A deep understanding of the composition of venoms and of the principles governing the
evolution of venomous systems is of applied importance for exploring the enormous …