For over a decade the term “Big data” has been used to describe the rapid increase in
volume, variety and velocity of information available, not just in medical research but in …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating
cellular biology at an unprecedented resolution, enabling the characterization of cellular …

High-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable
characterization of complex biological samples by increasing the number of cells that can be …

Colon mucus segregates the intestinal microbiota from host tissues, but how it organizes to
function throughout the colon is unclear. In mice, we found that colon mucus consists of two …

Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in …

The ability to generate T cells from pluripotent stem cells (PSCs) has the potential to
transform autologous T cell immunotherapy by facilitating universal, off-the-shelf cell …

Aging results in increased myelopoiesis, which is linked to the increased incidence of
myeloid leukemias and production of myeloid-derived suppressor cells. Here, we examined …

Although analysis of maternal plasma cell-free content has been employed for screening of
genetic abnormalities within a pregnancy, limited attention has been paid to its use for the …

Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-
ineffective and time-consuming. Here we report ImReP, a computational method for rapid …