Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Background: Plasma transfusions are most commonly used therapeutically for bleeding or
prophylactically in non-bleeding patients prior to invasive procedures or surgery. Although …

A general understanding of blood products and their modifications will help any physician
make good decisions about transfusion. The separation of blood into products makes the …

Over 7 years ago, the American Board of Internal Medicine Foundation (ABIM) created the
national Choosing Wisely campaign with the purpose of encouraging active dialogue …

BACKGROUND The ADAMTS13 test distinguishes thrombotic thrombocytopenic purpura
(TTP) from other thrombotic microangiopathies (TMAs). The PLASMIC score helps …

Background A pre‐plasma exchange ADAMTS13 measurement differentiates thrombotic
thrombocytopenic purpura (TTP) from other forms of thrombotic microangiopathy (TMA) …

Background Acquired haemophilia A (AHA), with potentially high risk of morbidity and
mortality, occurs as a result of inhibitors against factor VIII. Bleeding due to AHA can be …

Plasma for direct therapeutic use is a fast-evolving blood component in terms of its
production and presentation. More than a dozen forms are available worldwide, which is …

Background Acquired haemophilia A (AHA) is an autoimmune bleeding disorder with
significant morbidity and mortality. Bleeding AHA patients with high titre inhibitors can be …

Constituting up to 55% of our total blood volume, plasma consists of proteins including
albumin and immunoglobulins, clotting factors (procoagulants) and inhibitors …