Targeted nucleases have provided researchers with the ability to manipulate virtually any
genomic sequence, enabling the facile creation of isogenic cell lines and animal models for …

Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …

In bacteria and archaea, the clustered regularly interspaced short palindromic repeats
(CRISPR) and associated proteins (Cas) confer adaptive immunity against exogenous DNA …

CRISPR/Cas9 technology is currently considered the most advanced tool for targeted
genome engineering. Its sequence-dependent specificity has been explored for locus …

Antibodies that naturally develop in some individuals infected with human immunodeficiency
virus 1 (HIV-1) and are capable of broadly neutralizing diverse strains of HIV-1 are useful for …

Among the most significant findings in the pathogenesis of HIV infection was the discovery
that almost total depletion of intestinal CD4+ T cells occurs rapidly after SIV or HIV infection …

Vaccinal effect of HIV-1 antibody therapy : Current Opinion in HIV and AIDS Vaccinal effect of
HIV-1 antibody therapy : Current Opinion in HIV and AIDS Log in or Register Subscribe to …

Small interfering RNA (siRNA) application in therapy still faces a major challenge with the
lack of an efficient and specific delivery system. Current vehicles are often responsible for …

Human immunodeficiency virus (HIV-1) indefinitely persists, despite effective antiretroviral
therapy (ART), within a small pool of latently infected cells. These cells often display markers …

Despite efforts to develop effective treatments for eradicating HIV-1, a cure has not yet been
achieved. Whereas antiretroviral drugs target an actively replicating virus, latent …