Over the last ten years there has been a huge increase in development and applications of
organocatalysis in which the catalyst acts as a nucleophile. Amidines and guanidines are …

This review covers recent developments relating to organocatalyzed transformations by
chiral isothioureas (ITUs) since their original introduction by Birman in 2006. This class of …

The asymmetric annulation of a range of α, β-unsaturated acyl ammonium intermediates,
formed from isothiourea HBTM 2.1 and anhydrides with either 1, 3-dicarbonyls, β-ketoesters …

The piperidine and dihydropyridone motifs are a recognized feature of numerous structurally
diverse natural products and bioactive pharmaceuticals.[1] Among the synthetic methods …

HBTM-2.1 promotes the catalytic asymmetric intermolecular Michael-lactonisation of
arylacetic acids and trifluoromethylenones in the presence of pivaloyl chloride, giving C (6) …

HBTM-2.1 promotes the direct asymmetric α-amination of carboxylic acids with N-aryl-N-
aroyldiazenes at low catalyst loadings (as low as 0.25 mol%), giving either 1, 3, 4-oxadiazin …

Abstract A DMAP‐N‐oxide, featuring an α‐amino acid as the chiral source, was developed,
synthesized and applied in asymmetric Steglich rearrangement. A series of O‐acylated …

The first and asymmetric total syntheses of two C11-oxygenated hetisine-type diterpenoid
alkaloids, namely,(+)-davisinol and (+)-18-benzoyldavisinol, is described. The concise …

An organocatalytic asymmetric domino Mannich/cyclization reaction between 2-
benzothiazolimines with azlactones has been successfully developed. With the bifunctional …

The mechanism of esterification of the secondary alcohol 1-(1-naphthyl) ethanol 9 by
isobutyric anhydride catalyzed by 4-pyrrolidinopyridine (PPY, 11) and a series of single …