Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells.
Their products, ceramides (Cer), are components of cellular membranes but also mediate …

Sphingolipids including ceramides and its derivatives such as ceramide-1-phosphate,
glucosylceramide (GlcCer), and sphingosine-1-phosphate are essential structural …

Rationale Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important
mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in …

Treatment of triple-negative breast cancer (TNBC) is challenging because of its “COLD”
tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated …

Sphingolipids are a class of lipids that have important functions in a variety of cellular
processes such as, differentiation, proliferation, senescence, apoptosis and …

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various
biological processes and can control cell proliferation and survival, as well as being …

Radiation is a common anticancer therapy for prostate cancer, which transforms tumor-
associated normal fibroblasts to myofibroblasts, resulting in fibrosis. Oxidative stress caused …

Background Endogenous sphingolipid signaling has been shown to play an important role
in prostate cancer endocrine resistance. Methods The novel SphK2 inhibitor, ABC294640 …

The application of ultrasound and microbubbles (USMB) has been shown to enhance both
chemotherapy and radiotherapy. This study investigated the potential of triple combination …

Objective: Glucosylceramide (GC) synthesized by glucosylce-ramide synthase (GCS) favors
cell survival and proliferation in many cancers. However, it's role in Fms-like tyrosine kinase …