PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic

AN Martinez, C Talhari, MO Moraes… - PLoS Neglected …, 2014 - journals.plos.org
In leprosy, classic diagnostic tools based on bacillary counts and histopathology have been
facing hurdles, especially in distinguishing latent infection from active disease and …

Pure neuritic leprosy: latest advancements and diagnostic modalities: diagnosis of pure neuritic leprosy

N Razdan, S Sadhu - Diagnostic Microbiology and Infectious Disease, 2024 - Elsevier
Pure neuritic leprosy (PNL) is characterized by exclusive peripheral neuropathy without
dermatological alterations. Diagnosis is difficult since skin lesions and acid-fast bacilli (AFB) …

Self-reported clinical history of misdiagnosed leprosy cases in the State of Mato Grosso, Brazil, 2016-2019

KVRN Neves, LMG Machado… - Cadernos de Saúde …, 2023 - SciELO Public Health
This study aimed to analyze the self-reported clinical history of patients misdiagnosed with
leprosy in the State of Mato Grosso, Brazil. This is a cross-sectional study of new leprosy …

[HTML][HTML] Pure neural leprosy or amyloid neuropathy? Systematic review and clinical case report

LO Santos, TRMO Fernandes, TRS Barbosa… - Revista da Associação …, 2021 - SciELO Brasil
SUMMARY OBJECTIVE: To review the literature and to report a clinical case with initial
suspicion of pure neural leprosy and final diagnosis of amyloid neuropathy. METHODS: The …

Accuracy of Determine TB-LAM Ag to detect TB in HIV infected patients associated with diagnostic methods used in Brazilian public health units

A Benjamin, SC Cavalcante, LF Jamal… - Plos one, 2019 - journals.plos.org
Background Determine TB-LAM Ag (LAM) is a point of care test developed to diagnose
tuberculosis (TB). The aim of this study was to evaluate the diagnostic performance of LAM …

Neurologic complications of leprosy

TD Sabin, TR Swift - Aminoff's Neurology and General Medicine, 2014 - Elsevier
Leprosy is an important cause of nontraumatic peripheral neuropathy. Its main clinical
features are anesthetic skin lesions and peripheral neuropathy, but skin lesions are …

Overview of the histopathology and other laboratory investigations in leprosy

MMF Chan, BR Smoller - Current Tropical Medicine Reports, 2016 - Springer
Despite the significant reduction in global leprosy prevalence in the advent of multidrug
therapy, epidemiological evidence shows that new case detection rate in endemic countries …

[PDF][PDF] Pathogen detection

AB Fontes, FA Lara, AR Santos… - International …, 2017 - internationaltextbookofleprosy.org
Detection of acid-fast bacilli (AFB) by microscopy is recognized as the fastest, easiest, and
least expensive tool for the rapid identification of leprosy cases. In many regions where …

Hanseníase e laboratório: uma interação desafiadora

HSP Pedro, SMT Nardi… - BEPA. Boletim …, 2014 - periodicos.saude.sp.gov.br
O M. leprae é o agente da hanseníase. Por ser um bacilo não cultivável em meios definidos,
seu diagnóstico é essencialmente clínico. Pesquisas têm sido realizadas para desenvolver …

PCR–A DIAGNOSTIC TOOL FOR PURE NEURITIC LEPROSY.

PS Mohanasundari Balaji, N PP… - European Journal of …, 2023 - search.ebscohost.com
Introduction: The diagnosis of pure neural leprosy (PNL) remains difficult due to absence of
characteristic skin lesions. Prior to the advent of invasive nerve biopsy, patients with pure …