Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …

We are researchers and clinicians working on Alzheimer's disease (AD) or related topics,
and we write to express our concern that one particular aspect of the disease has been …

Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets
endowed with specific functions. The precise identity of these subsets is poorly …

Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …

Dysfunction of microglia is known to play an important role in Alzheimer's disease (AD).
Here, we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD …

Despite the enormity of the societal and health burdens caused by Alzheimer's disease
(AD), there have been no FDA approvals for new therapeutics for AD since 2003. This …

Inflammation is an adaptive response of the immune system to noxious insults to maintain
homeostasis and restore functionality. The retina is considered an immune-privileged tissue …

In a somewhat narrow diagnostic lens, Alzheimer disease (AD) has been considered a brain-
specific disease characterized by the presence of Aβ (β-amyloid) plaques and tau neural …

Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …