Better strategies for coronavirus (COVID-19) vaccination

N Tzenios, M Chahine, M Tazanios - … of the Medical Academy and other …, 2023 - sjmas.com
The first case of COVID-19 a coronavirus disease, was reported in December 2019 in
Wuhan, China, and spread globally. Severe acute respiratory syndrome coronavirus 2 …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C Xie, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022 - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

[PDF][PDF] Neutralization of SARS-CoV-2 Omicron sub-lineages BA. 1, BA. 1.1, and BA. 2

JP Evans, C Zeng, P Qu, J Faraone, YM Zheng… - Cell host & …, 2022 - cell.com
Recent reports of SARS-CoV-2 Omicron variant sub-lineages, BA. 1, BA. 1.1, and BA. 2,
have reignited concern over potential escape from vaccine-and infection-induced immunity …

Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape

Z Zhao, J Zhou, M Tian, M Huang, S Liu, Y Xie… - Nature …, 2022 - nature.com
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging
mutations on spike's properties, we performed systematic structural analyses on apo …

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation

DY Chen, CV Chin, D Kenney, AH Tavares, N Khan… - Nature, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …

[PDF][PDF] Cryo-EM structures of SARS-CoV-2 Omicron BA. 2 spike

V Stalls, J Lindenberger, SMC Gobeil, R Henderson… - Cell Reports, 2022 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sub-
lineage has gained in proportion relative to BA. 1. Because spike (S) protein variations may …

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant

W Zhang, K Shi, Q Geng, G Ye… - Proceedings of the …, 2022 - National Acad Sciences
The sudden emergence and rapid spread of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) omicron variant has raised questions about its animal …

Delta variant (B. 1.617. 2) of SARS-CoV-2: Mutations, impact, challenges and possible solutions

M Dhawan, A Sharma, N Priyanka… - Human vaccines & …, 2022 - Taylor & Francis
Since commencement of COVID-19 pandemic, several SARS-CoV-2 variants have emerged
amid containment efforts via vaccination. The Delta variant (B. 1.617. 2), discovered in …

Structural basis for human receptor recognition by SARS-CoV-2 Omicron variant BA. 1

Q Geng, K Shi, G Ye, W Zhang, H Aihara, F Li - Journal of Virology, 2022 - Am Soc Microbiol
The highly contagious and fast-spreading omicron variant of SARS-CoV-2 infects the
respiratory tracts efficiently. The receptor-binding domain (RBD) of the omicron spike protein …

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level

R Zhu, D Canena, M Sikora, M Klausberger… - nature …, 2022 - nature.com
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …