Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Astaxanthin is a member of the carotenoid family that is found abundantly in marine
organisms, and has been gaining attention in recent years due to its varied biological …

Aging results in an elevated burden of senescent cells, senescence‐associated secretory
phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low‐grade …

The ribotoxic stress response (RSR) is a signaling pathway in which the p38-and c-Jun N-
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …

Studies investigating whether there is a causative link between the gut microbiota and
lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan …

Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie
restriction (CR) potently extends health and lifespan, but is largely unachievable in humans …

Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or
relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of …

Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj
mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear …

Fibrillin-1 is an extracellular glycoprotein present throughout the body. Mutations in fibrillin-1
cause a wide spectrum of type I fibrillinopathies, including Marfan syndrome characterized …

Abstract “Western diet” containing high concentrations of sugar and fat consumed during
pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic …