Evolving new-age strategies to transport therapeutics across the blood-brain-barrier

M Choudhari, S Hejmady, RN Saha, S Damle… - International Journal of …, 2021 - Elsevier
A basic understanding of the blood–brain barrier (BBB) is essential for the novel
advancements in targeting drugs specific to the brain. Neoplasm compromising the internal …

Insulin mediated novel therapies for the treatment of Alzheimer's disease

SK Dubey, KK Lakshmi, KV Krishna, M Agrawal… - Life sciences, 2020 - Elsevier
Alzheimer's disease, a progressive neurodegenerative disorder, is one of the leading
causes of death in the USA, along with cancer and cardiac disorders. AD is characterized by …

Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery

KV Krishna, G Wadhwa, A Alexander… - ACS chemical …, 2019 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …

Therapeutic nanotechnologies for Alzheimer's disease: A critical analysis of recent trends and findings

P Delbreil, JM Rabanel, X Banquy… - Advanced Drug Delivery …, 2022 - Elsevier
Alzheimer's Disease (AD) is an irreversible neurodegenerative disease for which no
modifying therapies are presently available. Besides the identification of pathological …

Biophysical, Biochemical, and Behavioral Implications of ApoE3 Conjugated Donepezil Nanomedicine in a Aβ1–42 Induced Alzheimer's Disease Rat Model

KV Krishna, RN Saha, SK Dubey - ACS Chemical Neuroscience, 2020 - ACS Publications
Alzheimer's disease (AD) is a progressive neurological disorder and is the most common
type of dementia. Amyloid β (Aβ) plaques play an important role in the pathophysiology of …

Fluorescence-based method for sensitive and rapid estimation of chlorin e6 in stealth liposomes for photodynamic therapy against cancer

R Jain, R Pradhan, S Hejmady, G Singhvi… - Spectrochimica Acta Part …, 2021 - Elsevier
Chlorin e6 is a chlorine-based porphyrin containing photosensitizer mainly used for the
therapy in cancers like neck and head, early-stage lung cancer, and topical skin cancers …

Caffeine Improve Memory and Cognition via Modulating Neural Progenitor Cell Survival and Decreasing Oxidative Stress in Alzheimer's Rat Model

V Tiwari, A Mishra, S Singh… - Current Alzheimer …, 2023 - ingentaconnect.com
Aims: Caffeine possesses potent antioxidant, anti-inflammatory and anti-apoptotic activities
against a variety of neurodegenerative diseases, including Alzheimer's disease (AD) and …

Optimized method development and validation for determining donepezil in rat plasma: A liquid-liquid extraction, LC-MS/MS, and design of experiments approach

YB Shin, JH Kim, MK Kwon, JH Myung, DG Lee, SG Jin… - Plos one, 2024 - journals.plos.org
Donepezil (DPZ), a piperidine-based reversible cholinesterase inhibitor, finds extensive use
in treating Alzheimer's disease (AD). Originally designed as an oral formulation, DPZ …

Stability indicating liquid chromatographic method for simultaneous quantification of betamethasone valerate and tazarotene in in vitro and ex vivo studies of complex …

VK Rapalli, G Singhvi, S Gorantla… - Journal of separation …, 2019 - Wiley Online Library
Low‐potency corticosteroid betamethasone valerate and vitamin‐A tazarotene are used in
combination for effective treatment of psoriasis. There is no robust high‐performance liquid …

Tailor-made nanocargoes as promising tool for brain targeting: Modulated approaches with better therapeutic outcomes

V Kumar, U Gupta - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
The combination of nanotechnology and controlled release techniques is vital to effective
drug delivery into the brain. An in-depth and comprehensive overview of nanotechnology …