The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Schizophrenia is a debilitating mental illness which involves three groups of symptoms, ie,
positive, negative and cognitive, and has major public health implications. According to …

Belief in conspiracy theories—such as that the 9/11 terrorist attacks were an inside job or
that the pharmaceutical industry deliberately spreads diseases—is a widespread and …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Only relatively recently has it become clear that mammalian genomes encode tens of
thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed …

This paper considers psychotic symptoms in terms of false inferences or beliefs. It is based
on the notion that the brain is an inference machine that actively constructs hypotheses to …

The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …