Antibody-based approaches to target pancreatic tumours

M Sorbara, P Cordelier, N Bery - Antibodies, 2022 - mdpi.com
Pancreatic cancer is an aggressive cancer with a dismal prognosis. This is due to the
difficulty to detect the disease at an early and curable stage. In addition, only limited …

Review on Therapeutic Diversity of Oxazole Scaffold: An Update

D Patel, K Patel, S Patel, B Patel, A Patel - ChemistrySelect, 2024 - Wiley Online Library
Oxazole, a five‐membered cyclic ring containing oxygen and nitrogen, displays diverse
interactions and structural variations, enhancing its potential applications across various …

A Conditionally Activated Cytosol-Penetrating Antibody for TME-Dependent Intracellular Cargo Delivery

CS Dombrowsky, D Happel, J Habermann, S Hofmann… - Antibodies, 2024 - mdpi.com
Currently, therapeutic and diagnostic applications of antibodies are primarily limited to cell
surface-exposed and extracellular proteins. However, research has been conducted on cell …

Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer

M Sorbara, N Bery - Biochemical Society Transactions, 2021 - portlandpress.com
The RAS superfamily of small GTPases regulates major physiological cellular processes.
Mutation or deregulation of these small GTPases, their regulators and/or their effectors are …

Interactions Between Apolipoprotein E, Tau Protein, and 3-O-Sulfated Heparan Sulfate: Implications for Alzheimer's Disease Pathogenesis

D Mah - 2024 - search.proquest.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease typified by cognitive
decline and memory loss. AD stands as the leading cause of dementia and the 7 th most …