Immune determinants of the pre-metastatic niche

L Patras, L Shaashua, I Matei, D Lyden - Cancer Cell, 2023 - cell.com
Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis

XZ Huang, MJ Pang, JY Li, HY Chen, JX Sun… - Nature …, 2023 - nature.com
Peritoneal metastasis is the leading cause of death for gastrointestinal cancers. The native
and therapy-induced ascites ecosystems are not fully understood. Here, we characterize …

Obesity, dietary fats, and gastrointestinal cancer risk-potential mechanisms relating to lipid metabolism and inflammation

KAJ Mitchelson, F O'Connell, J O'Sullivan, HM Roche - Metabolites, 2024 - mdpi.com
Obesity is a major driving factor in the incidence, progression, and poor treatment response
in gastrointestinal cancers. Herein, we conducted a comprehensive analysis of the impact of …

Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases

LI Ibrahim, C Hajal, GS Offeddu, MR Gillrie, RD Kamm - Biomaterials, 2022 - Elsevier
Epithelial ovarian cancer has the highest mortality rate of any gynecologic malignancy and
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …

Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis

A Mukherjee, D Bezwada, F Greco, M Zandbergen… - Nature …, 2023 - nature.com
In the tumor microenvironment, adipocytes function as an alternate fuel source for cancer
cells. However, whether adipocytes influence macromolecular biosynthesis in cancer cells is …

Involvement of CXC chemokines (CXCL1-CXCL17) in gastric cancer: Prognosis and therapeutic molecules

A Ullah, J Zhao, J Li, RK Singla, B Shen - Life Sciences, 2024 - Elsevier
Gastric cancer (GC) is the fifth-most prevalent and second-most deadly cancer worldwide.
Due to the late onset of symptoms, GC is frequently treated at a mature stage. In order to …

[HTML][HTML] Emerging roles of CircRNA-miRNA networks in cancer development and therapeutic response

M Hashemi, EM Khosroshahi, P Daneii… - Non-coding RNA …, 2024 - Elsevier
The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer
and orchestrating intricate molecular interactions during tumor progression. Circular RNAs …

Pro‐tumoral behavior of omental adipocyte‐derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer

S Iyoshi, M Yoshihara, K Nakamura… - … Journal of Cancer, 2021 - Wiley Online Library
Adipocyte‐rich omentum offers “good soil” for disseminating ovarian cancer (OvCa),
contributing to therapeutic difficulty. However, little is understood about the association …

Exosomes from human omental adipose-derived mesenchymal stem cells secreted into ascites promote peritoneal metastasis of epithelial ovarian cancer

Q Qu, L Liu, Y Cui, Y Chen, Y Wang, Y Wang - Cells, 2022 - mdpi.com
Epithelial ovarian cancer (EOC) patients frequently develop peritoneal metastasis,
especially in the human omentum. However, the mechanism underlying this propensity …

LightGBM is an effective predictive model for postoperative complications in gastric Cancer: A study integrating radiomics with ensemble learning

W Wang, R Sheng, S Liao, Z Wu, L Wang, C Liu… - Journal of Imaging …, 2024 - Springer
Postoperative complications of radical gastrectomy seriously affect postoperative recovery
and require accurate risk prediction. Therefore, this study aimed to develop a prediction …