T lymphocytes with~/~ receptors recognize antigen in association with the polymorphic
products of the class I and class II loci of the major histocompatibility complex (MHC). This …

Publisher Summary This chapter presents an overview of T cell recognition and function.
Complex organisms coevolved with a wide variety of microorganisms—viruses, bacteria …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

Using a chemically homogeneous radiolabeled peptide of high specific activity (125 I-
QLSPYPFDL, 3.5× 10 18 cpm per mole) we show that at a peptide concentration (5 pM) …

CD8+ T‐cell responses are critical in the immunological control of tumours and infectious
diseases. To prime CD8+ T cells against these cell‐associated antigens, exogenous …

The relative roles of CD8, TCR: pepMHC affinity, and TCR: pepMHC dissociation rate in T
cell activation have remained controversial. To determine the relationships among these …

Crosspresentation of exogenous antigens (Ags) to CD8+ T cells by dendritic cells generally
requires their entry into the cytosol. Here we show that both soluble and phagocytosed …

THE mutant human cell line T2 is defective in antigen presentation in the context of class I
major histocompatibility complex (MHC) molecules1, 2 and also in that transfected T2 cells …

T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the
LC13 T cell receptor (TCR), selected for recognition on self-HLA-B∗ 0801 bound to a viral …

THE tyrosine kinase activity of c-Src is stimulated during mitosis by dephosphorylation of its
regulatory tyrosine residue1–3. This is associated with increased accessibility of its Src …