Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how
systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive …

Objectives Understanding the molecular mechanisms underlying human cartilage
degeneration and regeneration is helpful for improving therapeutic strategies for treating …

In this Review we focus on the initiation of autoantibody production and autoantibody
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …

Objectives To understand the molecular features distinguishing anti-citrullinated protein
antibodies (ACPA) from 'conventional'antibodies in rheumatoid arthritis (RA). Methods …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

The pathophysiological roles of mast cells are still not fully understood, over 140 years since
their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct …

The term osteoimmunology describes an interdisciplinary research field that links the
investigation of osteology (bone cells) with immunology. The crosstalk between innate and …

Control of cytokine production by immune cells is pivotal for counteracting infections via
orchestration of local and systemic inflammation. Although their contribution has long been …

Epidemiological findings suggest a potential role for anti-citrullinated protein antibodies
(ACPAs) in rheumatoid arthritis (RA) pathogenesis. ACPA-positive RA is associated with …