Drug metabolizing enzymes play a crucial role in the pharmacokinetics and
pharmacodynamics of therapeutic drugs, influencing their efficacy and safety. This review …

Background Variants of the estrogen receptor b (ESR2) gene have been associated with
different types of cancer. However, these associations have been inconsistent. We …

Breast cancer (BC) pathogenesis is poorly understood and not yet completely determined.
BC susceptibility genes are responsible for 20% to 25% of breast cancer risk. The main …

Objective To explore the value of uridine diphosphate-glucuronosyltransferase 2B7
(UGT2B7)-161 single nucleotide polymorphism in predicting the occurrence of cardiotoxicity …

Abstract Background Breast Cancer (BC) is the most common cancer in women worldwide
and, although 70% of patients are responsive to selective Estrogen Receptor (ER) …

Pesticide exposure is a risk factor for the development of several diseases, including breast
cancer (BC). The enzyme UGT2B7 participate in detoxification of pesticides and the …

Breast cancer as the most common cancer worldwide is influenced by genetic and
physiological factors. Based on some evidence indicating the role of estrogen receptor 1 …

BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the
regulation and differentiation of breast tumorigenesis. Some ERα polymorphisms, including …

Purpose Estrogen receptor 1 (ESR1) XbaI polymorphisms may affect breast cancer
susceptibility; however, the results of previously published studies are inconsistent. This …

Objective: In Jordan, breast cancer (BC) affects a substantial proportion of Jordanian
women, highlighting the need for studies to be carried out regarding the genetic component …