Abstract Major Depressive Disorder (MDD) is common among cancer patients, with
prevalence rates up to four-times higher than the general population. Depression confers …

Epidemiologically documented risk factors for carcinogenesis, including genetic, endocrine,
environmental, and socioeconomic factors, only account for part of the risk for cancer …

BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are widely used
antidepressants and one of the most commonly used medications. There is growing concern …

Neurotransmitters and hormones regulate major immune functions, including the selection
of T helper (Th) 1 or Th2 cytokine responses, related to cell-mediated and humoral immunity …

Fluoxetine, an antidepressant, has been indicated to elicit anti-cancer response in
hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC) in vitro. However …

Simple Summary Melanoma is a very aggressive and fatal malignant tumor. While curable if
diagnosed in its early stages, advanced melanoma, despite the complex therapeutic …

The arsenal of treatments for most cancers fit broadly into the categories of surgery,
chemotherapy, radiation, and targeted therapy. All represent proven and successful …

The antidepressant fluoxetine has been under discussion because of its potential influence
on cancer risk. It was found to inhibit the development of carcinogen-induced preneoplastic …

The activities of individual cells must be tightly coordinated in order to build and maintain
complex 3-dimensional body structures during embryogenesis and regeneration. Thus, one …

Two decades ago, it was hypothesized that antidepressants could alter the course of
neoplastic diseases. However, contradictory findings indicated that antidepressants could …