A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

A Hasan, BA Paray, A Hussain, FA Qadir… - Journal of …, 2021 - Taylor & Francis
The widespread antigenic changes lead to the emergence of a new type of coronavirus
(CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically …

Artificial intelligence for COVID-19 drug discovery and vaccine development

A Keshavarzi Arshadi, J Webb, M Salem… - Frontiers in Artificial …, 2020 - frontiersin.org
SARS-COV-2 has roused the scientific community with a call to action to combat the growing
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …

MolAICal: a soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm

Q Bai, S Tan, T Xu, H Liu, J Huang… - Briefings in …, 2021 - academic.oup.com
Deep learning is an important branch of artificial intelligence that has been successfully
applied into medicine and two-dimensional ligand design. The three-dimensional (3D) …

Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria

Y Muhammad, YA Kani, S Iliya… - SAGE open …, 2021 - journals.sagepub.com
Introduction: The COVID-19 is a pandemic caused by SARS-CoV-2 which has infected over
74 million people, killing more than 1,600,000 million people around the world as of 17th …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

Prediction of novel inhibitors of the main protease (M-pro) of SARS-CoV-2 through consensus docking and drug reposition

A Gimeno, J Mestres-Truyol, MJ Ojeda-Montes… - International journal of …, 2020 - mdpi.com
Since the outbreak of the COVID-19 pandemic in December 2019 and its rapid spread
worldwide, the scientific community has been under pressure to react and make progress in …

Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants

IA Guedes, LSC Costa, KB Dos Santos, ALM Karl… - Scientific Reports, 2021 - nature.com
The COVID-19 caused by the SARS-CoV-2 virus was declared a pandemic disease in
March 2020 by the World Health Organization (WHO). Structure-Based Drug Design …

Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus …

S Kumar, P Kashyap, S Chowdhury, S Kumar… - Phytomedicine, 2021 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19) playing havoc across the globe
caused 585,727 deaths and 13,616,593 confirmed cases so far as per World Health …

SARS‐CoV‐2: A comprehensive review from pathogenicity of the virus to clinical consequences

M Lotfi, N Rezaei - Journal of medical virology, 2020 - Wiley Online Library
Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which caused
novel coronavirus disease (COVID‐19) pandemic, is the worldwide challenge. The virus is …

[HTML][HTML] Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming

J Chen, Y Wang, Y Gao, LS Hu, J Yang, J Wang… - Biomedicine & …, 2020 - Elsevier
Qingfei Paidu decoction (QFPD), a multi-component herbal formula, has been widely used
to treat COVID-19 in China. However, its active compounds and mechanisms of action are …