Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

TB Gandek, L van der Koog… - Advanced healthcare …, 2023 - Wiley Online Library
A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

Exploring the impact of physicochemical properties of liposomal formulations on their in vivo fate

B Sheikholeslami, NW Lam, K Dua, M Haghi - Life Sciences, 2022 - Elsevier
Liposomes, vesicles composed of a phospholipid bilayer, are considered a remarkably
advanced drug delivery system due to their unique properties, including their …

Insight into the role of clathrin‐mediated endocytosis inhibitors in SARS‐CoV‐2 infection

SS Alkafaas, AM Abdallah, S Ghosh… - Reviews in Medical …, 2023 - Wiley Online Library
Emergence of SARS‐CoV‐2 variants warrants sustainable efforts to upgrade both the
diagnostic and therapeutic protocols. Understanding the details of cellular and molecular …

Antimicrobial peptides increase line tension in raft-forming lipid membranes

VR Koynarev, KKA Borgos, J Kohlbrecher… - Journal of the …, 2024 - ACS Publications
The formation of phase separated membrane domains is believed to be essential for the
function of the cell. The precise composition and physical properties of lipid bilayer domains …

Sphingolipids as modulators of SARS-CoV-2 infection

K Törnquist, MY Asghar, V Srinivasan… - Frontiers in Cell and …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic with severe consequences for afflicted individuals and the society as a whole …

Endosomal cholesterol in viral infections–a common denominator?

M Glitscher, E Hildt - Frontiers in Physiology, 2021 - frontiersin.org
Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually
all viruses. These seem to have developed manifold strategies to modulate the cholesterol …

Host membranes as drivers of virus evolution

M Matveeva, M Lefebvre, H Chahinian, N Yahi… - Viruses, 2023 - mdpi.com
The molecular mechanisms controlling the adaptation of viruses to host cells are generally
poorly documented. An essential issue to resolve is whether host membranes, and …

Convergent evolution dynamics of SARS-CoV-2 and HIV surface envelope glycoproteins driven by host cell surface receptors and lipid rafts: lessons for the future

J Fantini, H Chahinian, N Yahi - International journal of molecular …, 2023 - mdpi.com
Although very different, in terms of their genomic organization, their enzymatic proteins, and
their structural proteins, HIV and SARS-CoV-2 have an extraordinary evolutionary potential …