Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Biomimetic scaffolds supporting tissue regeneration are complex materials with
multifunctional characteristics. The unique biocompatibility and biodegradability of …

Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …

The lack of adequate blood/lymphatic vessels as well as low-potential articular cartilage
regeneration underlines the necessity to search for alternative biomaterials. Owing to their …

Abstract 3D printing has experienced swift growth for biological applications in the field of
regenerative medicine and tissue engineering. Essential features of bioprinting include …

Cartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in
hyaline cartilage regeneration, yet current approaches have limited success at reconstituting …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …