Simple Summary Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment
of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients …

Cancer immunotherapies can successfully activate immune responses towards certain
tumors. However, this can also result in the development of treatment-induced immune …

Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the
pathophysiology of this disease shares many similarities with human type 1 diabetes. Since …

OBJECTIVE To identify circulating proteins influencing type 1 diabetes susceptibility using
Mendelian randomization (MR). RESEARCH DESIGN AND METHODS We used a large …

Background Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-
inducible transcription factors that govern various essential metabolic activities in the liver …

Diabetes is a prevalent global health issue associated with significant morbidity and
mortality. Diabetic retinopathy (DR) is a well-known inflammatory, neurovascular …

Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and
lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects …

In type 1 diabetes (T1D) autoreactive CD8 T cells infiltrate pancreatic islets and destroy
insulin-producing β cells. Progression to T1D onset is a chronic process, which suggests …

Excessive NOD-like receptor thermal protein domain associated protein 3 (NLRP3)
inflammasome activation has an important function in the pathogenesis of Sjögren's …

Premature ovarian insufficiency (POI) critically affects female reproductive health, with
obesity being a significant and recognized risk factor. Interleukin-27 (IL-27), known for its …