Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Summary α2δ-1, commonly known as a voltage-activated Ca 2+ channel subunit, is a
binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is …

The mammalian brain contains few niches for neural stem cells (NSCs) capable of
generating new neurons, whereas other regions are primarily gliogenic. Here we leverage …

Aging drives a progressive decline in cognition and decreases synapse numbers and
synaptic function in the brain, thereby increasing the risk for neurodegenerative disease …

Voltage-gated calcium (Ca V) channels are associated with β and α 2 δ auxiliary subunits.
This review will concentrate on the function of the α 2 δ protein family, which has four …

Neuropathic pain affects more than one million people across the globe. The quality of life of
people suffering from neuropathic pain has been considerably declining due to the …

The auxiliary α2δ calcium channel subunits play key roles in voltage-gated calcium channel
function. Independent of this, α2δ-1 has also been suggested to be important for …

Painful peripheral neuropathy is a severe and difficult‐to‐treat neurological complication
associated with cancer chemotherapy. Although chemotherapeutic drugs such as paclitaxel …