Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and
fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and …

Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …

Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under
different physiological conditions. Recent discoveries have unveiled the relation between …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Within living cells, mitochondria are considered relevant sources of reactive oxygen species
(ROS) and are exposed to reactive nitrogen species (RNS). During the last decade …

Antigen presentation is essential for establishing immune tolerance and for immune
responses against infectious disease and cancer. Although antigen presentation can be …

The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner
mitochondrial membrane, is crucial for adapting mitochondrial function and preserving …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …