Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Cell-cell fusion is essential for fertilization and organ development. Dedicated proteins
known as fusogens are responsible for mediating membrane fusion. However, until recently …

Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …

Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …

Introduction Ageing is associated with an attenuated hypertrophic response to resistance
training and periods of training interruptions. Hence, elderly would benefit from the 'muscle …

Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell
sizes are variable and adaptable, but what governs cell size has been unclear. We find that …

Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

Cell fusion is essential for the development of multicellular organisms, and plays a key role
in the formation of various cell types and tissues. Recent findings have highlighted the …