Muscle specific signaling has been shown to originate from myofilaments and their
associated cellular structures, including the sarcomeres, costameres or the cardiac …

Titin, the so‐called “third filament” of the sarcomere, represents a difficult challenge for the
determination of damaging genetic variants. A single titin molecule extends across half the …

Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere,
responsible for passive force development at sarcomere length (SL) above the physiological …

Titin is a giant protein in the sarcomere that plays an essential role in muscle contraction
with actin and myosin filaments. However, its utility goes beyond mechanical functions …

The thick filament-associated A-band region of titin is a highly repetitive component of the
titin chain with important scaffolding properties that support thick filament assembly. It also …

Titin is the third contractile filament in the sarcomere, and it plays a critical role in sarcomere
integrity and both passive and active tension. Unlike the thick and thin filaments, which are …

Sequence comparison is critical for the functional assignment of newly identified protein
genes. As uncharacterized protein sequences accumulate, there is an increasing need for …

Titin, the largest muscle protein, plays an important role in passive tension, sarcomeric
integrity and cell signaling within the muscle. Recent work has also highlighted a role for titin …

The force produced by a muscle depends on its contractile history, yet human movement
simulations typically employ muscle models that define the force–length relationship from …

The N2A segment of titin functions as a pivotal hub for signal transduction and interacts with
various proteins involved in structural support, chaperone activities, and transcriptional …