Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management

KM Koo, PN Mainwaring, SA Tomlins… - Nature Reviews Urology, 2019 - nature.com
The accurate identification and stratified treatment of clinically significant early-stage
prostate cancer have been ongoing concerns since the outcomes of large international …

Prostate cancer liquid biopsy biomarkers' clinical utility in diagnosis and prognosis

M Matuszczak, JA Schalken, M Salagierski - Cancers, 2021 - mdpi.com
Simple Summary In prostate cancer, overdiagnosis and overtreatment is a common problem
for clinicians. Accurate diagnosis and prognosis are essential to avoid unnecessary biopsy …

[HTML][HTML] The long non-coding RNA PCA3: an update of its functions and clinical applications as a biomarker in prostate cancer

AEG Lemos, A da Rocha Matos, LB Ferreira - Oncotarget, 2019 - ncbi.nlm.nih.gov
Abstract Prostate cancer antigen 3 (PCA3) is an overexpressed prostate long non-coding
RNA (lncRNA), transcribed from an intronic region at the long arm of human chromosome …

[HTML][HTML] Biomarkers for detection of clinically significant prostate cancer: contemporary clinical data and future directions

NW Eyrich, TM Morgan, JJ Tosoian - Translational Andrology and …, 2021 - ncbi.nlm.nih.gov
Use of serum prostate-specific antigen (PSA) testing for early detection of prostate cancer
appears to reduce cancer-specific mortality. Due to the limited specificity of PSA for clinically …

New biomarkers for diagnosis and prognosis of localized prostate cancer

DA Chistiakov, VA Myasoedova, AV Grechko… - Seminars in cancer …, 2018 - Elsevier
The diagnostics and management of localized prostate cancer is complicated because of
cancer heterogeneity and differentiated progression in various subgroups of patients. As a …

Metastatic castration-resistant prostate cancer: insights on current therapy and promising experimental drugs

S Ferretti, C Mercinelli, L Marandino… - … and Reports in …, 2023 - Taylor & Francis
The therapeutic landscape of metastatic hormone sensitive and metastatic castration-
resistant prostate cancer (mCRPC) is rapidly changing. We reviewed the current treatment …

Urinary biomarkers in prostate cancer detection and monitoring progression

D Wu, J Ni, J Beretov, P Cozzi, M Willcox… - Critical reviews in …, 2017 - Elsevier
Prostate cancer (CaP) is the most common cancer in men and the second leading cause of
cancer deaths in males in Australia. Although serum prostate-specific antigen (PSA) has …

Urinary RNA-based biomarkers for prostate cancer detection

F Martignano, L Rossi, A Maugeri, V Gallà… - Clinica Chimica …, 2017 - Elsevier
Prostate cancer (PCa) is the commonest malignancy in the male population worldwide.
Serum prostate specific antigen (PSA) test is the most important biomarker for the detection …

Urinary MyProstateScore (MPS) to rule out clinically-significant cancer in men with equivocal (PI-RADS 3) multiparametric MRI: addressing an unmet clinical need

JJ Tosoian, U Singhal, MS Davenport, JT Wei… - Urology, 2022 - Elsevier
Objective To evaluate the complementary value of urinary MyProstateScore (MPS) testing
and multiparametric MRI (mpMRI) and assess outcomes in patients with equivocal mpMRI …

MyProstateScore in men considering repeat biopsy: validation of a simple testing approach

JJ Tosoian, MS Sessine, BJ Trock, AE Ross… - Prostate cancer and …, 2023 - nature.com
Background Men with persistent risk of Grade Group (GG)≥ 2 cancer after a negative biopsy
present a unique clinical challenge. The validated MyProstateScore test is clinically …