Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …

Acute kidney injury (AKI) and diabetes mellitus (DM) are public health problems that cause a
high socioeconomic burden worldwide. In recent years, the landscape of AKI etiology has …

Toll-like receptor-4 (TLR4) and sodium-glucose co-transporter 2 (SGLT2) signaling is
involved in the pathogenesis of diabetes-associated kidney diseases. The purpose of this …

Introduction: Kidney stones (KSs) are associated with hematuria and renal failure and pose
a significant clinical and public health concern. Diabetes is associated with a higher risk of …

Abstract Aim Targeting Toll-like receptor 4 (TLR4) and Angiotensin II type 1 receptor (AT1R)
could provide renoprotection during acute kidney injury (AKI) mainly by regulating …

Mitophagy maintains cellular homeostasis by eliminating damaged mitochondria.
Accumulated damaged mitochondria can lead to oxidative stress and cell death. Induction of …

Highlights•Kidney diseases cause high morbidity and mortality worldwide.•Target-specific
therapies are missing for many kidney diseases.•Novel druggable targets for kidney disease …

Alleviating vascular barrier injury improves colitis. Angiotensin converting enzyme
2/angiotensin 1-7/Mas receptor (ACE2/Ang1-7/MasR) axis-related drugs have various …

Acute kidney injury to chronic kidney disease (AKI-to-CKD) transition is a complex
intermingling of characteristics of both AKI and CKD. Pathophysiologically, the transition …

Acute kidney injury (AKI) represents a significant challenge to global public health problem
and is associated with poor outcomes. There is still considerable debate about the effect of …