Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

National Cancer Institute workshop on proton therapy for children: considerations regarding brainstem injury

D Haas-Kogan, D Indelicato, H Paganetti… - International Journal of …, 2018 - Elsevier
Purpose Proton therapy can allow for superior avoidance of normal tissues. A widespread
consensus has been reached that proton therapy should be used for patients with curable …

Proton beams in cancer treatments: clinical outcomes and dosimetric comparisons with photon therapy

J Doyen, AT Falk, V Floquet, J Hérault… - Cancer treatment …, 2016 - Elsevier
Purpose To review current evidence of the role of proton therapy (PT) in other tumors than
skull base, sinusal/parasinusal, spinal and pediatric tumors; to determine medico-economic …

Biological considerations when comparing proton therapy with photon therapy

H Paganetti, P Van Luijk - Seminars in radiation oncology, 2013 - Elsevier
Owing to the limited availability of data on the outcome of proton therapy, treatments are
generally optimized based on broadly available data on photon-based treatments. However …

Evolution of advanced technologies in prostate cancer radiotherapy

NG Zaorsky, AS Harrison, EJ Trabulsi… - Nature Reviews …, 2013 - nature.com
Conventional treatment options for clinically localized, low-risk prostate cancer include
radical prostatectomy, external-beam radiotherapy (EBRT) and low-dose-rate …

Near real-time automated dose restoration in IMPT to compensate for daily tissue density variations in prostate cancer

T Jagt, S Breedveld, S Van de Water… - Physics in Medicine …, 2017 - iopscience.iop.org
Proton therapy is very sensitive to daily density changes along the pencil beam paths. The
purpose of this study is to develop and evaluate an automated method for adaptation of …

Irradiation with protons for the individualized treatment of patients with locally advanced rectal cancer: a planning study with clinical implications

HA Wolff, DM Wagner, LC Conradi, S Hennies… - Radiotherapy and …, 2012 - Elsevier
BACKGROUND AND PURPOSE: Ongoing clinical trials aim to improve local control and
overall survival rates by intensification of therapy regimen for patients with locally advanced …

Degradation of target coverage due to inter-fraction motion during intensity-modulated proton therapy of prostate and elective targets

S Thörnqvist, LP Muren, L Bentzen, LB Hysing… - Acta …, 2013 - Taylor & Francis
Internal target and organ motion during treatment is a challenge in radiotherapy (RT) of the
prostate and the involved elective targets, with residual motion being present also following …

Impact of delivery time factor on treatment time and plan quality in tomotherapy

T Yagihashi, T Inoue, S Shiba, A Yamano… - Scientific Reports, 2023 - nature.com
Delivery time factor (DTF) is a new parameter introduced by the RayStation treatment
planning system for tomotherapy treatment planning. This study investigated the effects of …

[HTML][HTML] Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer

S Tilbæk, LP Muren, A Vestergaard, L Stolarczyk… - Clinical and translational …, 2023 - Elsevier
Abstract The Danish Prostate Cancer Group is launching the randomized trial, PROstate
PROTON Trial 1 (NCT05350475), that compares photons and protons to the prostate and …