The α-ketoamide motif is widely found in many natural products and drug candidates with
relevant biological activities. Furthermore, α-ketoamides are attractive candidates to …

Controllable production of α‐keto amides and amides from the same substrates is an
attractive goal in the field of transition‐metal‐catalyzed (double‐) carbonylation. Herein, a …

The review focuses on the methods of synthesis of 2-(1-alkoxyalkylidene)-1, 3-dicarbonyl
compounds and their chemical transformations. The reactivity of such compounds toward …

Abstract Although long known, 1, 2‐and 1, 3‐dicarbonyl compounds have recently come
more and more to prevalence as ideal substrates for the invention of new stereoselective …

A wide range of N-tosyl α-ketoamides underwent transamidation with various alkyl amines in
the absence of a catalyst, base, or additive. On the other hand, transamidation in N-Boc α …

The unique physicochemical properties of water as a solvent have attracted great interest
from synthetic chemists for many years, and tremendous research progress on chemical …

Enantioselective Mannich reactions of pyruvates catalyzed by amine-based catalyst
systems, in which pyruvates act as nucleophiles, are reported. The reactions of pyruvates …

α-Keto amides are a key frame in biology, medicinal chemistry and synthetic chemistry as
drug molecules and key intermediates. Based on the structural aspect, an acyclic α-keto …

An enantioselective [3+ 2] cycloaddition reaction between nitrile oxides and transiently
generated enolates of α-keto esters has been developed. The catalyst system was found to …

Chiral metal catalysts have been widely applied to asymmetric transformations. However,
the electronic structure of the catalyst and how it contributes to the activation of the substrate …