Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

In this study, we investigated the mechanisms through which astrocyte-derived exosomes
(AS-Exos) alleviate traumatic brain injury (TBI)-induced neuronal defects in TBI model rats …

Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …

Abstract Traumatic Brain Injury (TBI) is caused by the external physical assaults damages
the brain. It is a heterogeneous disorder that remains a leading cause of death and disability …

Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death
and disability worldwide, although its prevention measures and clinical cares are …

The survival and function of brain cells requires uninterrupted ATP synthesis. Different brain
structures subserve distinct neurological functions, and therefore have different energy …

Targeting drugs to the mitochondrial level shows great promise for acute and chronic
treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the …

A better understanding of the secondary injury mechanisms that occur after traumatic spinal
cord injury (SCI) is essential for the development of novel neuroprotective strategies linked …

Rationale: Traumatic brain injury (TBI) leads to neurological impairment, with no satisfactory
treatments available. Classical ketogenic diets (KD), which reduce reliance on …