Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
Human serum albumin binders: a piggyback ride for long-acting therapeutics
Highlights•A variety of albumin-binding moieties (ABMs) have been developed for half-life
extension of short-lived drugs.•Various drugs can incorporate a selected ABM for in situ HSA …
extension of short-lived drugs.•Various drugs can incorporate a selected ABM for in situ HSA …
[HTML][HTML] Comprehensive structure and functional adaptations of the yeast nuclear pore complex
CW Akey, D Singh, C Ouch, I Echeverria, I Nudelman… - Cell, 2022 - cell.com
Nuclear pore complexes (NPCs) mediate the nucleocytoplasmic transport of
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Interventions against variants of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) are urgently needed. Stable and potent nanobodies (Nbs) that target the receptor …
CoV-2) are urgently needed. Stable and potent nanobodies (Nbs) that target the receptor …
Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV
A Ramon, M Ali, M Atkinson, A Saturnino… - Nature Machine …, 2024 - nature.com
Monoclonal antibodies have emerged as key therapeutics. In particular, nanobodies, small,
single-domain antibodies that are naturally expressed in camelids, are rapidly gaining …
single-domain antibodies that are naturally expressed in camelids, are rapidly gaining …
Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses
Globally, there is an urgency to develop effective, low-cost therapeutic interventions for
coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent …
coronavirus disease 2019 (COVID-19). We previously generated the stable and ultrapotent …
NanoNet: Rapid and accurate end-to-end nanobody modeling by deep learning
T Cohen, M Halfon… - Frontiers in …, 2022 - frontiersin.org
Antibodies are a rapidly growing class of therapeutics. Recently, single domain camelid
VHH antibodies, and their recognition nanobody domain (Nb) appeared as a cost-effective …
VHH antibodies, and their recognition nanobody domain (Nb) appeared as a cost-effective …
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape
The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic
antibodies and urgently demands powerful new therapeutics that can resist viral escape. We …
antibodies and urgently demands powerful new therapeutics that can resist viral escape. We …
Recent advances in predicting protein–protein interactions with the aid of artificial intelligence algorithms
Protein–protein interactions (PPIs) are essential in the regulation of biological functions and
cell events, therefore understanding PPIs have become a key issue to understanding the …
cell events, therefore understanding PPIs have become a key issue to understanding the …
Progress and challenges in mass spectrometry-based analysis of antibody repertoires
Humoral immunity is divided into the cellular B cell and protein-level antibody responses.
High-throughput sequencing has advanced our understanding of both these fundamental …
High-throughput sequencing has advanced our understanding of both these fundamental …