Neuromuscular disorders encompass a heterogeneous group of conditions that impair the
function of muscles, motor neurons, peripheral nerves, and neuromuscular junctions. Being …

Skeletal muscle damaged by injury or by degenerative diseases such as muscular
dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon …

As we enter the new millennium, the prospects for the field of Biomedical Engineering are
bright. Individuals interested in pursuing careers in this field continue to increase and the …

The transplantation of cultured myoblasts into mature skeletal muscle is the basis for a new
therapeutic approach to muscle and non-muscle diseases: myoblast-mediated gene …

Satellite cells are dormant progenitors located at the periphery of skeletal myofibers that can
be triggered to proliferate for both self-renewal and differentiation into myogenic cells. In …

Muscular dystrophies are a heterogeneous group of genetic diseases, characterized by
progressive degeneration of skeletal and cardiac muscle. Despite the intense investigation …

Background Myoblast transfer has been proposed as a technique to replace dystrophin, the
skeletal-muscle protein that is deficient in Duchenne's muscular dystrophy. Donor myoblasts …

Myoblasts, the precursors of skeletal muscle fibers, can be induced to withdraw from the cell
cycle and differentiate in vitro. Recent studies have also identified undifferentiated …

Muscular dystrophies are a group of genetic muscle disorders that cause progressive
muscle weakness and degeneration. Within this group, Duchenne muscular dystrophy …

Myoblast transplantation has been extensively studied as a gene complementation
approach for genetic diseases such as Duchenne Muscular Dystrophy. This approach has …