This article shows the latest advances in the spectroscopic analysis of cancer cells to identify
pathological changes and understand the mechanism of metastasis using stimulated …

Accumulating evidence including studies of AHR-deficient mice and TCDD toxicity suggests
multiple physiologic AHR functions. Challenges to identify responsible mechanisms are due …

Uncontrolled inflammation is linked to poor outcomes in sepsis and wound healing, both of
which proceed through distinct inflammatory and resolution phases. Eicosanoids are a class …

To understand mechanisms of response to BET inhibitors (BETi), we mined the Beat AML
functional genomic data set and performed genome-wide CRISPR screens on BETi …

Studies of induced granulocytic differentiation help to reveal molecular mechanisms of cell
maturation. The nuclear proteome represents a rich source of regulatory molecules …

In this study, we have tested the hypothesis that the expression and secretion of galectins
are driven through mechanisms globally impacted by homeostatic regulation involving the …

NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O 2−), which has
functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex …

Multiple studies have established the synergy between ATO and ATRA in APL, and a
combination of these drugs without chemotherapy is the new standard of care in low and …

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to
retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating …

Label-free measurement is essential to understand the metabolism of drug molecules
introduced into cells. Raman imaging is a powerful method to investigate intracellular drug …